Week 10 NFL Odds 2026: The 49ers Add Keenan Allen Before Visiting the Cowboys

Week 10 NFL Odds

Week 10 has 14 games, with the Bears, Broncos, Eagles, and Buccaneers on bye. Below are the spreads, totals, and moneylines for every game, with DraftKings and Novig prices side by side.

Novig is a peer-to-peer prediction market: you trade with other members, and there's no vig built into the price. Every market on this page is a pre-game straight trade, which carries no fee on Novig. A sportsbook builds its margin into each price it posts, and that shows up in most of the comparisons below. DraftKings is still the cheaper price on four sides this week, and each one is noted in its game.

All odds on this page were pulled Tuesday, Nov. 10, 2026. DraftKings prices were read at 4:34 p.m. ET and Novig prices from 4:35 to 4:37 p.m. ET. Lines move until kickoff, so check the live number before you trade.

Every Week 10 market is also on Novig's live NFL board.

Week 10 NFL Schedule and Odds

Odds from DraftKings Sportsbook as of Tuesday, Nov. 10, 4:34 p.m. ET. Moneyline win % is the probability each DraftKings moneyline implies with the book's margin left in, so the two teams in a game add up to more than 100%. Home win prob is the home team's chance with the margin removed. Patriots vs. Lions is played in Munich, with Detroit as the designated home team. The Bears, Broncos, Eagles, and Buccaneers are on bye.

NFL Spreads Week 10

Jacksonville is the biggest favorite on the board, 10.5 points at Tennessee at both venues. The Rams give 9.5 in Arizona, and Buffalo gives 8.5 at DraftKings and 7.5 on Novig against the Jets. Seattle is next, 6 at DraftKings and 6.5 on Novig in Las Vegas.

Panthers at Saints is the tightest spread at 1.5. Seven teams are favored on the road: the Jaguars, Rams, Bills, Seahawks, Texans, 49ers, and Chiefs. Detroit gives 2.5 to New England in Munich.

NFL Totals Week 10

49ers at Cowboys has the highest total of the week at 55.5, four points clear of Patriots vs. Lions at 51.5. Bills at Jets is next at 50.5, then Steelers at Bengals at 49.5.

The lowest total at DraftKings is 38.5, shared by Dolphins at Colts and Chargers at Ravens. Texans at Browns and Rams at Cardinals sit at 39.5. Novig has Dolphins at Colts at 37.5, a point under DraftKings and the lowest number on either board.

NFL Moneylines Week 10

Jacksonville is the largest moneyline favorite, at 85.7% at DraftKings and 84% on Novig. Buffalo (82.9% and 81%) and the Rams (81.0% and 81%) are close behind, and Seattle is 73.5% at DraftKings and 73% on Novig.

Panthers at Saints is the closest game on the moneyline: New Orleans is 55.0% at DraftKings and 54% on Novig, Carolina 49.5% and 48%. Thursday's opener is next, with the Giants at 56.5% and 57%.

NFL Lines and Line Shopping Week 10

Odds are from DraftKings Sportsbook as of 4:34 p.m. ET and from Novig as of 4:35 to 4:37 p.m. ET on Tuesday, Nov. 10.

This section compares Week 10 prices at DraftKings and Novig, game by game. Novig shows each side as a percentage, which is the price of a contract that pays $1 if that side wins. DraftKings posts American odds, so we convert each DraftKings price to the probability it implies, with the book's margin left in. That puts both columns on the same scale: for the same side, the lower percentage is the cheaper price.

Novig rounds each percentage to the nearest whole number, so where the two prices fall within that rounding, we call the side even. Where the two venues post a different spread or total, the market label shows both numbers and we don't call a winner on that market.

Across the 70 sides where both venues post the same number, Novig is the cheaper price on 52, DraftKings on four, and 14 are even.

Commanders vs. Giants Odds

The Giants are favored at home, -2.5 at DraftKings against -1.5 on Novig, and the total is 41.5 at both venues. Novig is the cheaper price on both sides of the total and on the Commanders moneyline, 44% against 47.6%. The Giants moneyline is even.

Patriots vs. Lions Odds: New England Heads to Munich Without Rhamondre Stevenson

New England comes off a 45-27 loss to Green Bay in which Drake Maye threw three interceptions, and Rhamondre Stevenson is expected to miss the next few weeks with a knee injury. Detroit is a 2.5-point favorite at both venues, with the total at 51.5. Novig is the cheaper price on all six sides, including the Patriots moneyline at 42% against 44.6%.

Chiefs vs. Falcons Odds: Kansas City Trades for Josh Downs

Kansas City sent fourth- and fifth-round picks to the Colts for receiver Josh Downs and a seventh-round pick on Tuesday, with Xavier Worthy carrying a hamstring injury out of the 35-12 win over the Jets. The Chiefs are 3.5-point road favorites at both venues, with the total at 45.5. Novig is the cheaper price on the Chiefs spread (47% against 50.5%), the over (49% against 51.2%), and the Falcons moneyline (37% against 40.0%). The Falcons spread, the under, and the Chiefs moneyline are even.

Texans vs. Browns Odds

Houston gives 4.5 on the road at both venues, and both post 39.5 on the total. Novig is the cheaper price on the Browns spread, the under (48% against 51.9%), and both moneylines. DraftKings is cheaper on the over, 52.8% against 54%, and the Texans spread is even.

Vikings vs. Packers Odds: Minnesota Brings Back Kirk Cousins

Minnesota reacquired Kirk Cousins from the Raiders for a 2027 third-round pick on Tuesday, a day after losing 23-6 to Buffalo with Kyler Murray out with a hamstring strain. Green Bay is a 3.5-point home favorite at both venues, and the total is 41.5 at DraftKings against 42.5 on Novig. Novig is the cheaper price on the Packers spread (49% against 52.4%) and the Vikings moneyline (39% against 41.7%). DraftKings is cheaper on the Vikings spread, 52.4% against 53%, and the Packers moneyline is even.

Jaguars vs. Titans Odds

Jacksonville is a 10.5-point road favorite at both venues against the 1-7 Titans, with the total at 46.5. Novig is the cheaper price on all six sides, by 0.8 to 2.4 percentage points; the Jaguars moneyline is 84% on Novig against 85.7% at DraftKings.

Dolphins vs. Colts Odds

Indianapolis is a 3.5-point home favorite at both venues, and the total is 38.5 at DraftKings against 37.5 on Novig. Novig is the cheaper price on the Colts spread and both moneylines, including the Dolphins at 37% against 39.4%. The Dolphins spread is even.

Panthers vs. Saints Odds

New Orleans is a 1.5-point home favorite at both venues, the smallest spread of the week, with the total at 48.5. Novig is the cheaper price on five of six sides, including the Panthers spread at 52% against 53.5%. DraftKings is cheaper on the under, 51.2% against 53%.

Bills vs. Jets Odds: Buffalo Adds Amani Hooker

Buffalo, 7-1 after a 23-6 win in Minnesota, traded a second-round pick to Tennessee for safety Amani Hooker and a fifth-round pick on Tuesday. The Bills are favored by 8.5 at DraftKings and 7.5 on Novig, and the total is 50.5 at both venues. Novig is the cheaper price on both sides of the total and both moneylines. The Bills are 81% on Novig against 82.9% at DraftKings.

Seahawks vs. Raiders Odds: Fernando Mendoza Takes Over in Las Vegas

Fernando Mendoza, the No. 1 overall pick, is set to start for Las Vegas after the Cousins trade, and Drew Lock starts again for Seattle with Sam Darnold out. Seattle is favored by 6 at DraftKings and 6.5 on Novig, with the total at 40.5 at both venues. Novig is the cheaper price on both sides of the total and both moneylines, with the Raiders at 28% against 30.8%.

Rams vs. Cardinals Odds

Both venues have the Rams -9.5 in Arizona, and the total is 39.5 at DraftKings against 40.5 on Novig. Novig is the cheaper price on both spreads and the Cardinals moneyline, 21% against 23.3%. The Rams moneyline is even.

49ers vs. Cowboys Odds: San Francisco Adds Keenan Allen

San Francisco traded a 2027 sixth-round pick to Indianapolis for Keenan Allen on deadline day, and Allen could play Sunday with Ricky Pearsall on injured reserve and Mike Evans dealing with Achilles tendinitis. The 49ers are 7-1 after a 38-17 win over the Raiders, and Dallas is 4-5 after beating the Colts 27-23. San Francisco is favored by 3.5 at DraftKings and 4.5 on Novig, and the 55.5 total is the highest of the week at both venues. Novig is the cheaper price on the under (50% against 51.2%) and the Cowboys moneyline (34% against 37.0%). The over and the 49ers moneyline are even.

Steelers vs. Bengals Odds: First Place in the AFC North

Both teams are 6-2, so Sunday night is for first place in the AFC North, after Pittsburgh won the Week 3 meeting 30-27. Cincinnati is a 3.5-point home favorite at both venues, with the total at 49.5. Novig is the cheaper price on the Bengals spread (50% against 52.4%), both sides of the total, and the Steelers moneyline (38% against 40.8%). The Steelers spread and the Bengals moneyline are even.

Chargers vs. Ravens Odds

Baltimore gives 4.5 at home to the 0-8 Chargers at both venues, and the 38.5 total ties Dolphins at Colts for the lowest at DraftKings. Novig is the cheaper price on the Chargers spread, the under (50% against 52.4%), and the Chargers moneyline (33% against 37.0%). DraftKings is cheaper on the Ravens moneyline, 67.2% against 68%. The Ravens spread and the over are even.

Most Traded Week 10 Markets on Novig

Volume traded on Novig as of Tuesday, Nov. 10, 4:37 p.m. ET. Thursday's game leads with $198,444, about 52 hours before kickoff, and Vikings at Packers is second at $171,908, ahead of Dolphins at Colts at $107,523. The Sunday games are five days out and the Monday game six, so their totals will keep building toward kickoff.

Prices on this page will move before kickoff. The live Week 10 markets are on Novig's NFL board.

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