Week 2 NFL Odds 2026: Spreads, Totals, Moneylines - and Why Novig Beats the Books

Week 2 NFL Odds

Week 2 is here. Below, we break down Week 2 NFL odds across spreads, totals, and moneylines, and show where Novig's prices beat sportsbooks like DraftKings so you can see, game by game, how better pricing turns small edges into long-term value.

If you care about getting the best possible price on every NFL side and total, where you trade matters as much as what you bet. Instead of paying fees baked into sportsbook odds, Novig's peer-to-peer market and no house edge lead to better prices than traditional books.

All odds on this page were pulled Thursday, Sept. 17, 2026. DraftKings prices are as of 8:08 p.m. ET (7:53 p.m. for Seahawks at Cardinals) and Novig prices are as of 7:51 p.m. ET. Lines move until kickoff, so check the live number before you trade.

Here are the NFL odds for every game in Week 2, which you can also follow in real time on Novig's live events page.

Week 2 NFL Schedule and Odds

Odds from DraftKings Sportsbook as of Thursday, Sept. 17, 8:08 p.m. ET. Win probability is the home team's implied chance from the moneyline with the vig removed.

NFL Spreads Week 2

The largest spread this week belongs to the San Francisco 49ers, who are 13.5-point favorites at home over the Miami Dolphins. It's the only double-digit line on the board. The Tampa Bay Buccaneers are next at 8.5 against the Cleveland Browns, then the Baltimore Ravens at 7.5 against the New Orleans Saints.

Everything else is 7 or closer. Three games sit at 2.5: Panthers at Falcons, Bengals at Texans and Jaguars at Broncos. Four road teams are favored, the Panthers in Atlanta, the Eagles in Tennessee, the Packers with the Jets and the Seahawks in Arizona.

NFL Totals Week 2

Two games in Week 2 have an over/under of at least 50 points. Lions at Bills opens the week at 54.5, the highest number on the board, with Commanders at Cowboys next at 50.5.

The lowest over/under of the week belongs to the Philadelphia Eagles and the Tennessee Titans at 39.5 points. Three games sit at 41.5: Steelers at Patriots, Browns at Buccaneers and Seahawks at Cardinals.

NFL Moneylines Week 2

The largest moneyline favorite this week is the San Francisco 49ers at -900, the heaviest price on the board by some distance. The Buccaneers at -455, the Ravens at -395 and the Rams at -375 are the next three.

Three games are close to a coin flip on the moneyline. Bengals at Texans is Houston -142 and Cincinnati +120, and both Panthers at Falcons and Jaguars at Broncos price the favorite at -148 against +124 on the dog.

NFL Lines and Line Shopping Week 2

Odds are provided from DraftKings Sportsbook as of Thursday, Sept. 17 at 8:08 p.m. ET and from Novig as of Thursday, Sept. 17 at 7:51 p.m. ET.

This overview compares Week 2 lines and odds across DraftKings and Novig to show where the best prices can be found. Novig displays each side as a percentage, which is the price of a contract that pays $1 if that side wins. The Novig column below converts those percentages to American odds, with the percentage shown alongside. Where the two venues post a different spread or total, the market label shows both numbers.

1. DET Lions vs BUF Bills

The Buffalo Bills are a solid favorite at home against the Detroit Lions, in the highest-total game of the week at 54.5. Both venues have Buffalo at -5.5 and the total at 54.5, and Novig is the better price on all six sides.

2. CAR Panthers vs ATL Falcons

The Carolina Panthers are a slight favorite on the road against the Atlanta Falcons, one of three games on the board at 2.5. Both venues agree on the spread and the 43.5 total, and Novig is the better price on all six sides.

3. MIN Vikings vs CHI Bears

The Chicago Bears are a solid favorite at home against the Minnesota Vikings. Both venues have Chicago at -4.5, but the total is 48.5 at DraftKings against 47.5 on Novig, so that market isn't a like-for-like comparison. Novig pays more on both spread sides and both moneylines.

4. PHI Eagles vs TEN Titans

The Philadelphia Eagles are a heavy favorite on the road against the Tennessee Titans, in the lowest-total game of the week. Novig has Philadelphia at -6.5 against -7 at DraftKings, a half point on the key number of 7, so the spread isn't a like-for-like comparison. DraftKings is the better price on the Eagles moneyline. Novig pays more on the Titans at +300 against +250, and on both sides of the total.

5. PIT Steelers vs NE Patriots

The New England Patriots are a solid favorite at home against the Pittsburgh Steelers. The two venues post different spreads, New England -5.5 at DraftKings against -4.5 on Novig. Novig is better on both sides of the total and on the Steelers moneyline at +212 against +180. DraftKings is better on the Patriots moneyline.

6. GB Packers vs NYJ Jets

The Green Bay Packers are a solid favorite on the road against the New York Jets. Both venues have Green Bay at -3.5 and the total at 44.5. Novig pays more on the Packers on both the spread and the moneyline, and on both sides of the total. DraftKings is the better price on both Jets sides.

7. CLE Browns vs TB Buccaneers

The Tampa Bay Buccaneers are the second-heaviest favorite of the week at home against the Cleveland Browns. Both venues agree on the 8.5 spread and the 41.5 total, and Novig is the better price on all six sides.

8. NO Saints vs BAL Ravens

The Baltimore Ravens are a heavy favorite at home against the New Orleans Saints. Baltimore is -7.5 at DraftKings against -8.5 on Novig, so the spread isn't a like-for-like comparison. Novig is better on the over and on both moneylines, with the Saints at +355 against +310. DraftKings is better on the under.

9. CIN Bengals vs HOU Texans

The Houston Texans are a slight favorite at home against the Cincinnati Bengals, the tightest moneyline on the board. Both venues have Houston at -2.5, but the total is 46.5 at DraftKings against 45.5 on Novig. Novig is the better price on both spread sides and both moneylines.

10. JAX Jaguars vs DEN Broncos

The Denver Broncos are a slight favorite at home against the Jacksonville Jaguars. Both venues have Denver at -2.5 and the total at 45.5. Novig is better on both spread sides, both moneylines and the under. The over is the same price at both.

11. LV Raiders vs LAC Chargers

The Los Angeles Chargers are a heavy favorite at home against the Las Vegas Raiders. Both venues agree on the 6.5 spread and the 43.5 total, and Novig is the better price on all six sides.

12. WAS Commanders vs DAL Cowboys

The Dallas Cowboys are a solid favorite at home against the Washington Commanders, in the highest-total Sunday game at 50.5. Dallas is -3.5 at DraftKings against -4.5 on Novig, so the spread isn't a like-for-like comparison. Novig pays more on both sides of the total and both moneylines.

13. SEA Seahawks vs ARI Cardinals

The Seattle Seahawks are a solid favorite on the road against the Arizona Cardinals. Seattle is -3.5 at DraftKings against -4.5 on Novig. Novig is better on both sides of the total and on both moneylines.

14. MIA Dolphins vs SF 49ers

The San Francisco 49ers are the heaviest favorite of the week at home against the Miami Dolphins, the only double-digit spread on the board. Both venues have San Francisco at -13.5, but the total is 44.5 at DraftKings against 45.5 on Novig. Novig pays more on both spread sides and on the Dolphins moneyline at +809 against +600. DraftKings is better on the under, and the 49ers moneyline is -900 at both.

15. IND Colts vs KC Chiefs

The Kansas City Chiefs are a heavy favorite at home against the Indianapolis Colts in the Sunday night game. Both venues have Kansas City at -6.5 and the total at 46.5. Novig is better on the Chiefs spread, both sides of the total and both moneylines. DraftKings is better on the Colts spread at +100.

16. NYG Giants vs LAR Rams

The Los Angeles Rams are a heavy favorite at home against the New York Giants in the Monday night game that closes Week 2. The two venues differ on both numbers, the Rams -7 at DraftKings against -7.5 on Novig and the total 48.5 against 47.5. Novig is better on the Rams spread, the under and the Rams moneyline. DraftKings is better on the Giants spread, the Giants moneyline and the over.

Most Traded Week 2 Markets on Novig

Volume traded on Novig as of Thursday, Sept. 17. The Thursday opener has drawn about eight times the volume of any other Week 2 game.

If you're trading NFL this week, the gap between a decent line and the best available price adds up. Most bettors leave it on the table. Check all live NFL markets on Novig before placing your next trade.