Week 1 NFL Odds 2026: Spreads, Totals, Moneylines

Week 1 NFL Odds

Week 1 is here. Below, we break down Week 1 NFL odds across spreads, totals, and moneylines, and show where Novig's prices beat sportsbooks like DraftKings so you can see, game by game, how better pricing turns small edges into long-term value.

If you care about getting the best possible price on every NFL side and total, where you trade matters as much as what you bet. Instead of paying fees baked into sportsbook odds, Novig's peer-to-peer market and no house edge lead to better prices than traditional books.

All odds as of Thursday, Sept. 4, 2026. Lines move until kickoff, so check the live number before you trade.

Here are the NFL odds for every game in Week 1, which you can also follow in real time on Novig's live events page: (https://novig.com/events).

Week 1 NFL Schedule and Odds

Odds from DraftKings Sportsbook as of Monday, Sept. 1. Win probability is the home team's implied chance from the moneyline with the vig removed.

NFL Spreads Week 1

The largest spread this week belongs to the Los Angeles Chargers, who are 10.5-point favorites at home over the Arizona Cardinals. It's the only double-digit line on the board. The Jacksonville Jaguars are 7.5-point favorites against the Cleveland Browns, and the Detroit Lions are favored by 7 to the New Orleans Saints.

Everything else is 4.5 or closer. Three games sit at 1.5: Bills at Texans, Jets at Titans and Packers at Vikings. Three road teams are favored, the Ravens in Indianapolis, the Bears in Carolina and the Cowboys at the Giants.

NFL Totals Week 1

One game in Week 1 has an over/under of at least 50 points. The Tampa Bay Buccaneers at the Cincinnati Bengals at 51.5 promises a thrilling watch, with Saints at Lions next at 49.5.

The lowest over/under on Sunday's slate belongs to the New York Jets and the Tennessee Titans at 38.5 points. Browns at Jaguars and Dolphins at Raiders are both 40.5.

NFL Moneylines Week 1

The largest moneyline favorite this week is the Los Angeles Chargers at -575, the heaviest price on the board. The Jaguars at -380 and the Lions at -305 are the other two favorites above -300.

Two games are close to a coin flip on the moneyline. Bills at Texans is Buffalo -118 and Houston -102, and Packers at Vikings is Minnesota -118 and Green Bay -102.

NFL Lines and Line Shopping Week 1

This overview compares Week 1 lines and odds across DraftKings and Novig to show where the best prices can be found. Novig displays each side as a percentage, which is the price of a contract that pays $1 if that side wins.

The Novig column below converts those percentages to American odds, with the percentage shown alongside. Where the two venues post a different spread or total, the market label shows both numbers.

1. NE Patriots vs SEA Seahawks

The Seattle Seahawks are a solid favorite in their Week 1 matchup against the New England Patriots, a rematch of Super Bowl LX. Price is more favorable on Novig on both spread sides, the under and both moneylines. DraftKings is a shade better on the over.

2. SF 49ers vs LA Rams

The Los Angeles Rams are a solid favorite in their Week 1 matchup against the San Francisco 49ers, the NFL's first ever regular-season game in Australia. Price is more favorable on Novig on the 49ers spread, the over and both moneylines. DraftKings is better on the Rams spread and the under.

3. CHI Bears vs CAR Panthers

The Chicago Bears are a slight road favorite in their Week 1 matchup against the Carolina Panthers. Price is more favorable on Novig on both spread sides, the over and the Panthers moneyline. DraftKings is better on the under and the Bears moneyline.

4. TB Buccaneers vs CIN Bengals

The Cincinnati Bengals are a solid favorite in their Week 1 matchup against the Tampa Bay Buccaneers, and this is the highest total of the week. Price is more favorable on Novig on both spread sides and both moneylines. The total itself differs, 51.5 at DraftKings and 50.5 on Novig.

5. BAL Ravens vs IND Colts

The Baltimore Ravens are a solid road favorite in their Week 1 matchup against the Indianapolis Colts. Indianapolis had gone 2-12-1 in its previous 15 season openers before beating Miami in Week 1 last year. Novig pays more on the Ravens spread and both moneylines, DraftKings on the Colts spread. The total is a point lower on Novig, 47.5 against 48.5.

6. BUF Bills vs HOU Texans

The Buffalo Bills are a slight road favorite in their Week 1 matchup against the Houston Texans, and the moneyline is nearly even at both venues. Price is more favorable on Novig on the Bills spread, both sides of the total and the Bills moneyline. DraftKings is better on the Texans spread and the Texans moneyline.

7. NO Saints vs DET Lions

The Detroit Lions are a heavy favorite in their Week 1 matchup against the New Orleans Saints. Novig has Detroit at -6.5 against -7 at DraftKings, so the spread isn't a like-for-like comparison. The total is 49.5 at both, where Novig is a cent better on the under and DraftKings is better on the over. Novig pays more on both moneylines.

8. NYJ Jets vs TEN Titans

The Tennessee Titans are a slight favorite in their Week 1 matchup against the New York Jets, in the lowest-total game of the week. The two venues disagree on both numbers: Tennessee is -2.5 on Novig and -1.5 at DraftKings, and the total is 39.5 on Novig against 38.5. On the moneyline, Novig is better on the Titans and DraftKings on the Jets.

9. ATL Falcons vs PIT Steelers

The Pittsburgh Steelers are a solid favorite in their Week 1 matchup against the Atlanta Falcons. DraftKings has Pittsburgh at -3 and Novig at -3.5, a half point across the key number of 3. The total is 42.5 at both, where DraftKings is better on both sides. Novig pays more on both moneylines.

10. CLE Browns vs JAX Jaguars

The Jacksonville Jaguars are a heavy favorite in their Week 1 matchup against the Cleveland Browns. Price is more favorable on Novig on both spread sides and both moneylines, and the Browns moneyline pays +355 against +300. DraftKings is better on both sides of the total.

11. ARI Cardinals vs LAC Chargers

The Los Angeles Chargers are the heaviest favorite of the week in their Week 1 matchup against the Arizona Cardinals. Novig has the Chargers at -9.5 with a 47.5 total, against -10.5 and 46.5 at DraftKings, so the spread and total aren't a like-for-like comparison. On the moneyline Novig pays more on both sides.

12. GB Packers vs MIN Vikings

The Minnesota Vikings are a slight favorite in their Week 1 matchup against the Green Bay Packers. The total is 45.5 at DraftKings and 46.5 on Novig. On the spread, Minnesota is even money on Novig against -102 at DraftKings, and Novig pays more on both spread sides and both moneylines.

13. MIA Dolphins vs LV Raiders

The Las Vegas Raiders are a solid favorite in their Week 1 matchup against the Miami Dolphins. Price is more favorable on Novig on the Raiders spread and the Raiders moneyline, and on DraftKings on the Dolphins spread and the Dolphins moneyline. The total is 40.5 at DraftKings and 39.5 on Novig.

14. WAS Commanders vs PHI Eagles

The Philadelphia Eagles are a solid favorite in their Week 1 matchup against the Washington Commanders. Novig has Philadelphia at -5.5 with a 44.5 total, against -4.5 and 45.5 at DraftKings. On the moneyline Novig pays more on Washington and DraftKings on Philadelphia.

15. DAL Cowboys vs NYG Giants

The Dallas Cowboys are a slight road favorite in their Week 1 matchup against the New York Giants on Sunday night. Price is more favorable on Novig on the Giants spread, the over and the Giants moneyline, and on DraftKings on the Cowboys spread, the under and the Cowboys moneyline.

16. DEN Broncos vs KC Chiefs

The Kansas City Chiefs are a slight favorite in their Week 1 matchup against the Denver Broncos on Monday night. Novig has Kansas City at -2.5 with a 43.5 total, against -3 and 42.5 at DraftKings, so Denver backers get the key number of 3 only at DraftKings. Novig pays more on both moneylines.

Most Traded Week 1 Markets on Novig

Volume traded on Novig as of Thursday, Sept. 4. The Wednesday opener has drawn more than twice the volume of any other Week 1 game so far.

If you're trading NFL this week, the gap between a decent line and the best available price adds up. Most bettors overlook what can be a very significant edge. Check all live NFL markets on Novig before placing your next trade.